Project Details:
Solubility data of compounds relevant to human health. Solubility of substances related to urolithiasis
| Project No.: | 2002-035-1-500 |
| Start date: | 2003-01-01 |
| End date: | 0000-00-00 |
| Division: | Analytical Chemistry Division |
Series: Solubility Data Series; editor-in-chief: Mark Salomon
The prevention and treatment of crystal deposition in the human bodyare based on the understanding of the physico-chemical properties underlyingthe precipitation of the substances involved. Amongst these properties,the solubilities of the crystals are very important. In the scope ofurolithiasis, there are more than 20 different types of kidney stonescomposed of calcium oxalate hydrates (mono-, di- and trihydrate), ammoniummagnesium phosphate (struvite), calcium phosphates (hydroxyapatite andbrushite), uric acid and urates, cystine and xanthine. Solubilitiesof these substances can be incorporated in databases of sophisticatedsoftware packages that permit solubility calculations in artificialurine solutions. The results of these simulations would lead to someunderstanding and/or useful suggestions regarding the cause, preventionand treatment of renal or bladder calculi. Nevertheless, proper modellingof the solubilities of these substances requires reliable solubilityconstants. Thus it is necessary to critically assess the literaturevalues reported for these substances. Recently, two reviews on thissubject have been published:[1] E. Königsberger and L.-C. Tran-Ho, Solubility of substancesrelated to urolithiasis - Experiments and computer modelling. CurrentTopics in Solution Chemistry, 2:183-202 (1997).
[2] E. Königsberger and L.-C. Königsberger, Thermodynamicmodelling of crystal deposition in humans. PureAppl. Chem.,73:785-797 (2001).
G. Sadovska, I. Kron and E. Königsberger. Solubility of uric acidin lithium chloride solutions. Monatsh. Chem., 134:787-790,2003. [doi:10.1007/s00706-002-0588-2]
> Nov 2004 report update (pdffile - 10KB)
To be published as part of the IUPAC-NIST Solubility Data Series. inJ. Phys. Chem. Ref. Data; estimated to be completed during 2006/7.
> May 2006 report update (pdffile - 13KB)
> July 2007 report update (pdffile - 8KB)
1 book and 2 book chapters related to the project were published recently:
- Biomineralization- Medical Aspects of Solubility. E. Königsberger and L.C. Königsberger(eds.) Wiley, 2006, 284 pp.
- E. Königsberger and L.C. Königsberger. Solubility phenomenarelated to normal and pathological biomineralisation processes. In:Biomineralization - Medical Aspects of Solubility. E. Königsbergerand L.C. Königsberger (eds.), John Wiley & Sons, 1-37, 2006.
- E. Königsberger and L.-C. Königsberger. Solubility and body fluids. In: Thermodynamics,Solubility and Environmental Issues. T. Letcher (ed.), Elsevier,445-461, 2007.