Project Details:

Solubility of Benzoic Acid and Substituted Benzoic Acids in Both Neat Organic Solvents and Organic Solvent Mixtures (Solubility Data Series)

Project No.:2013-018-1-500
Start date:2013-05-24
End date:2013-10-01
Division:Analytical Chemistry Division

To compile and evaluate published experimental solubility data for benzoic acid and substituted benzoic acids dissolved in organic solvents and organic solvent mixtures. The solubility behavior of sixty or more benzoic acid compounds will be examined.


This volume reviews experimentally determined solubility data for benzoic acid and more than 63 substituted benzoic acids dissolved in neat organic solvents and well-defined binary and ternary organic solvent mixtures retrieved from the published chemical and pharmaceutical literature covering the period between 1990 to the end of 2012. Several substituted benzoic acids and benzoic acid derivatives exhibit therapeutic properties. For example, 2-hydroxybenzoic acid (commonly known as salicylic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used to alleviate aches and pains, and is a key ingredient in many “over-the-counter” and prescription skin-care products for the treatment of acne, psoriasis, corns, warts, calluses, and seborrhoeic dermatitis. Salicylic acid is also an ingredient in shampoos added to control dandruff and dry scalp. Its methyl ester, methyl salicylate, can be applied topically as a liniment to relieve joint and muscle pains. 2-Acetoxybenzoic acid (aspirin) is widely used and prescribed in the treatment of a number of medical conditions, including fever, muscle aches and pains, rheumatoid arthritis and pericarditis. 2-Acetoxybenzoic acid has also been used long-term, at low doses, to help prevent heart attacks, strokes, and blood clot formation in individuals at high risk of developing blood clots. 4-Aminobenzoic acid is one of the components of the folic acid molecule, and is an effective chemical sunscreen (absorbs ultraviolet and visible sun light) when applied topically. 4-Aminosalicylic acid is an antibiotic, prescribed alone or in combination with other drugs, in the treatment of tuberculosis. 5-Amino-2-hydroxybenzoic acid is a drug used for treating ulcerative colitis, which is a chronic inflammation of the large intestine.


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> October 2013 - Project completed

IUPAC-NIST Solubility Data Series. 99. Solubility of Benzoic Acid and Substituted Benzoic Acids in Both Neat Organic Solvents and Organic Solvent Mixtures, J. Phys. Chem. Ref. Data 42, 033103 (2013);

Last update: 1 Oct 2013