Project Details:

Environmental implications of endocrine active substances: Present state-of-the-art and future research needs

Project No.:2000-016-1-600
Start date:2000-01-01
End date:2003-10-30
Division:Chemistry and the Environment Division

To review the state of the art, to identify and prioritize research needs and to facilitate risk assessment and communication. A comprehensive evaluation of the issue of endocrine active substances will constitute an extension to the previous report PAC 70(9), 1998. It is hoped that such document will be of great help to public authorities, industry and the public in framing policies to address the issue.

Remarks: IUPAC/SCOPE Project -discussed and approved at the 42nd SCOPE Executive Committee meetingin Beijing in April 2000.
> SCOPE website <>


The project originates from the SCOPE/IUPAC joint meeting in February 1997 to more closely collaborate with each other. At the 10th SCOPE General Assembly in Piscataway, USA, in June 1998, the endocrine disrupter was adopted as one of such collaborative trials, with J. Miyamoto representing IUPAC asked to be proposant of the project.

It intends to widen and to deepen the aspects dealt with in Special Issues on Natural and Anthropogenic Environmental Estrogens published in Pure and Applied Chemistry Vol. 70, No. 9 (1998), and to present scientifically most authoritative views on the endocrine disrupter problems by incorporating the latest findings.

In each of the five topics identified (see progress section below), subtopics are envisaged to select most significant and urgent subjects to help solve the burning issues.


Four topics have been identified and will be coordinated as follow:

> Draft contents

The final reports are expected for publication in Pure and Applied Chemistry in 2003. Simultaneously, an executive summary will be prepared, to be addressed to non-experts including industry, regulatory agency, NGP, related national and international organizations, as well as mass media, etc.

As a milestone of the project, an International Symposium was organized and held in 17-21 November 2002, Yakohama, Japan. All the draft reports were presented; inputs from outside scientists, discussed.

This project was presented at a postersession at the IUPAC Congress/GA July 2001

>view pdf - 130KB<

To receive further information on this Symposium,contact K. Kubota; email: <>.

> See Symposiumannouncement in Chem. Int. 23(5), p. 56, 2001

> DownloadSecond Circular (pdf file - 266KB) (Jan 2002)

> DownloadThird Circular (pdf file - 439KB) (Jul 2002)

> 'Afterworkshop' update published in Chem. Int. 25(2), 2003

Project completed - The final report constitute a doubleissue of Pureand Applied Chemistry,75 (11/12), 2003. The Executive Summary is readily