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Pure Appl. Chem. Vol. 75, No. 2-3, pp. 141-419 (2003)

Pure and Applied Chemistry

Vol. 75, Issues 2-3


7502 Special Issue CoverSpecial Topic Issue on the Theme of Natural Products
This issue includes reviews and research papers based on lectures presented at the 23 rd IUPAC International Symposium on the Chemistry of Natural Products, Florence, Italy, 28 July - 2 August 2002. It was coordinated by Prof. J. Bull, IUPAC Special Topics
Editor, and Prof. Bruno Botta, Chairman of the Organizing Committee.

> Publication announced in CI July 2003 issue

Preface, B.Botta

Part 1: Design and Synthesis of Bioactive Targets

Inspirations from nature. New reactions, new therapeutic leads, and new drug delivery systems
P. A. Wender, J. L. Baryza, S. E. Brenner, M. O. Clarke, G. G. Gamber, J. C. Horan, T. C. Jessop, C. Kan, K. Pattabiraman, and T. J. Williams
p. 143 [Abstract] [full text - pdf 325 KB]

Antiangiogenic heparin-derived heparan sulfate mimics
B. Casu and A. Naggi
p. 157 [Abstract] [full text - pdf 383 KB]

Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin
G. Höfle, N. Glaser, T. Leibold, U. Karama, F. Sasse, and H. Steinmetz
p. 167 [Abstract] [full text - pdf 299 KB]

Synthesis of carbohydrate-based antibiotics
C.-H. Wong, M. C. Bryan, P. T. Nyffeler, H. Liu, and E. Chapman
p. 179 [Abstract] [full text - pdf 253 KB]

DNA minor-groove binders. Design, synthesis and biological evaluation of ligands structurally related to CC-1065, distamycin, and anthramycin
P. G. Baraldi, M. A. Tabrizi, D. Preti, F. Fruttarolo, B. Avitabile, A. Bovero, G. Pavani, M. del Carmen Nunez Carretero, and R. Romagnoli
p. 187 [Abstract] [full text - pdf 198 KB]

HIV-1 integrase inhibitors that block HIV-1 replication in infected cells. Planning synthetic derivatives from natural products
R. Di Santo, R. Costi, M. Artico, E. Tramontano, P. La Colla, and A. Pani
p. 195 [Abstract] [full text - pdf 561 KB]

Part 2: Synthetic Methodology and Total Synthesis

New and old challenges in total synthesis. From concept to practice
S. Hanessian, R. Margarita, A. Hall, S. Johnstone, M. Tremblay, and L. Parlanti
p. 209 [Abstract] [full text - pdf 330 KB]

Chemoenzymatic methods for the enantioselective preparation of sesquiterpenoid natural products from aromatic precursors
M. G. Banwell, A. J. Edwards, G. J. Harfoot, K. A. Jolliffe, M. D. McLeod, K. J. McRae, S. G. Stewart, and M. Vögtle
p. 223 [Abstract] [full text - pdf 211 KB]

Total synthesis of (-)-clavukerin A
E. L. Grimm, J.-L. Methot, and M. Shamji
p. 231 [Abstract] [full text - pdf 171 KB]

Progress in fumagillin synthesis
W. Picoul, O. Bedel, A. Haudrechy, and Y. Langlois
p. 235 [Abstract] [full text - pdf 484 KB]

Total syntheses of 11-deoxytetrodotoxin and 8,11-dideoxytetrodotoxin
T. Nishikawa, D. Urabe, K. Yoshida, T. Iwabuchi, M. Asai, and M. Isobe
p. 251 [Abstract] [full text - pdf 266 KB]

Biomimetic approach toward the stereoselective synthesis of acetogenins
R. V. A. Orru, B. Groenendaal, J. van Heyst, M. Hunting, C. Wesseling, R. F. Schmitz, S. F. Mayer, and K. Faber
p. 259 [Abstract] [full text - pdf 203 KB]

Microencapsulated methylrhenium trioxide (MTO)/H2O2 systems for the oxidation of cardanol derivatives
R. Saladino, E. Mincione, O. A. Attanasi, and P. Filippone
p. 265 [Abstract] [full text - pdf 227 KB]

Enantioselective synthesis and biological evaluation of a-hydroxylated lactone lignans
M. Sefkow, M. Raschke, and C. Steiner
p. 273 [Abstract] [full text - pdf 300 KB]

Stereocontrolled construction of conformationally constrained and rigid bis(a-amino acid) derivatives
K. Undheim, J. Efskind, and G. B. Hoven
p. 279 [Abstract] [full text - pdf 414 KB]

Part 3: Structure and Structure –Activity of Natural Products

Stereochemical analysis of natural products. Approaches relying on the combination of NMR spectroscopy and computational methods
R. Riccio, G. Bifulco, P. Cimino, C. Bassarello, and L. Gomez-Paloma
p. 295 [Abstract] [full text - pdf 338 KB]

Exploitation of proteomics strategies in protein structure-function studies
G. Marino, P. Pucci, L. Birolo, and M. Ruoppolo
p. 309 [Abstract] [full text - pdf 737 KB]

Prion protein allotype profiling by mass spectrometry
M. E. Schininà, B. Maras, F. Cardone, C. Mancone, S. Principe, M. A. Di Bari, P. Parchi, and M. Pocchiari
p. 317 [Abstract] [full text - pdf 207 KB]

Toxins from Adriatic blue mussels. A decade of studies
P. Ciminiello, C. Dell'Aversano, E. Fattorusso, M. Forino, and S. Magno
p. 325 [Abstract] [full text - pdf 265 KB]

Bioactive macrolides and polyketides from marine dinoflagellates
J. Kobayashi, K. Shimbo, T. Kubota, and M. Tsuda
p. 337 [Abstract] [full text - pdf 244 KB]

Detection of pharmacologically active natural products using ecology. Selected examples from Indopacific marine invertebrates and sponge-derived fungi
P. Proksch, R. Ebel, R. A. Edrada, P. Schupp, W. H. Lin, Sudarsono, V. Wray, and K. Steube
p. 343 [Abstract] [full text - pdf 198 KB]

Chemical studies on plant leaf movement controlled by a biological clock
M. Ueda, T. Sugimoto, Y. Sawai, T. Ohnuki, and S. Yamamura
p. 353 [Abstract] [full text - pdf 450 KB]

Structural flexibility of hyaluronan oligomers as probed by molecular modelling
A. Tafi, F. Manetti, F. Corelli, S. Alcaro, and M. Botta
p. 359 [Abstract] [full text - pdf 224 KB]

Part 4: Biosynthesis and Biotransformations of Natural Products

Functional genomics approach to the study of triterpene biosynthesis
Y. Ebizuka, Y. Katsube, T. Tsutsumi, T. Kushiro, and M. Shibuya
p. 369 [Abstract] [full text - pdf 208 KB]

Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis. Elucidation and distribution
M. Rohmer
p. 375 [Abstract] [full text - pdf 266 KB]

Biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum
L. Ning, H. Guo, X. Jiang, K. Bi, and D. Guo
p. 389 [Abstract] [full text - pdf 168 KB]

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis. Discovery and function of the ispDEFGH genes and their cognate enzymes
F. Rohdich, S. Hecht, A. Bacher, and W. Eisenreich
p. 393 [Abstract] [full text - pdf 282 KB]

Natural and totally synthetic receptors in the innovative design of HPLC chiral stationary phases
F. Gasparrini, I. D'Acquarica, D. Misiti, M. Pierini, and C. Villani
p. 407 [Abstract] [full text - pdf 190 KB]

Combination of enzymatic procedures with multicomponent condensations
R. Ostaszewski, D. E. Portlock, A. Fryszkowska, and K. Jeziorska
p. 413 [Abstract] [full text - pdf 172 KB]


authors index

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