Pure Appl. Chem., 2000, Vol. 72, No. 3, pp. 447-461
doi:10.1351/pac200072030447
ANALYTICAL CHEMISTRY DIVISION
COMMISSION ON MICROCHEMICAL TECHNIQUES AND TRACE ANALYSIS
Species-selective determination of selenium compounds in biological materials (Technical Report)
R. Lobinski , J. S. Edmonds , K. T. Suzuki , and P. C. Uden
1Warsaw University of Technology, Faculty of Chemistry, Department of Analytical Chemistry, ul. Noakowskiego 3, 00-664 Warszawa, Poland; 2CNRS UMR 5034, Hélioparc, 2, av. Pr. Angot, 64 000 Pau, France; 3Department of Chemistry, De Montfort University, The Gateway, Leicester LE1 9BH, UK; 4Faculty of Pharmaceutical Sciences, Chiba University, Inage, Chiba 263-8522, Japan; 5Department of Chemistry, University of Massachusetts, Amherst, MA 01003-4510, USA
Abstract:
There is substantial evidence of the complexity of selenium speciation in living organisms and of the importance of the selective determination of the particular species of this element in order to understand its metabolism and biological significance in clinical chemistry, biology, toxicology, and nutrition. The state-of-the-art of analytical techniques available for this purpose is critically evaluated with particular emphasis on the element-selective detection and identification of the detected selenium compounds. Whereas there are a number of techniques available that are able to detect various selenium species in living organisms selectively, few techniques exist that are able to identify and to characterize the species detected.