Pure Appl. Chem., 2003, Vol. 75, No. 10, pp. 1453-1475
doi:10.1351/pac200375101453
Ring opening of heterocycles by an arene-catalyzed lithiation*
M. Yus
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo.99, 03080 Alicante, Spain
Abstract:
The ring opening of different three-, four-, five-and six-membered oxygen-, nitrogen- and sulfur-containing saturated heterocycles using lithium and a catalytic amount of an arene (naphthalene or DTBB) yields a series of functionalized organolithium compounds, which, by reaction with different electrophiles, allow the preparation of polyfunctionalized molecules in only one synthetic operation.
*Lecture presented at the 4th Florida Heterocyclic Conference, Gainesville, Florida, 10-12 March 2003. Other presentations are published in this issue, pp. 1403-1475.
All articles from the 4th Florida Heterocyclic Conference, Gainesville, Florida, USA, 10–12 March 2003.