Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 235-249
doi:10.1351/pac200375020235
Progress in fumagillin synthesis*
W. Picoul, O. Bedel, A. Haudrechy, and Y. Langlois
Laboratoire de Synthèse des Substances Naturelles,Associé au CNRS, Université de Paris-Sud, F-91405 Orsay, France
Abstract:
After a brief account of the syntheses previously described in literature, several approaches of the antiangiogenic sesquiterpene fumagillin are described. Particularly, a Claisen–Ireland ring-closing metathesis strategy allowed the stereoselective preparation of several advanced intermediates in the fumagillin synthesis.