Pure Appl. Chem., 2003, Vol. 75, No. 2-3, pp. 389-393
doi:10.1351/pac200375020389
Biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum*
L. Ning, H. Guo, X. Jiang, K. Bi, and D. Guo
1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China; 2Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China
Abstract:
The biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum was investigated. After six days of incubation, five products were obtained. On the basis of chemical and spectral evidence, their structures were elucidated as epitriptolide-14-O-β-d-glucoside, 5α-hydroxytriptonide, triptolide, triptodiolide, and 2β-hydroxytriptonide, among which epitriptolide-14-O-β-d-glucoside and 5α-hydroxytriptonide are new compounds.