Pure Appl. Chem., 2004, Vol. 76, No. 2, pp. 365-374
http://dx.doi.org/10.1351/pac200476020365
Synthesis of texaphyrin conjugates
Abstract:
This paper summarizes recent synthetic efforts devoted to the generation of new, second-generation texaphyrin-type drugs, specifically species that involve known or potential anticancer agents covalently attached to a tumor-localizing texaphyrin core. Particular emphasis will be placed on the strategies needed to prepare such systems, as well as on the choice of active group being subject to attachment.