Pure and Applied Chemistry

Abstract: The review surveys the reactions of electron-deficient azaaromatic compounds with mono- and bifunctional nucleophilies in which a nucleophilic attack at the unsubstituted CH carbon of an aromatic ring is one of the key steps. Use of the S_N^H methodology for the synthesis of fused heterocyclic systems by means of nucleophilic addition –addition A_N–A_N, addition –substitution of hydrogen A_N–S_N^H, tandem substitution of hydrogen S_N^H–S_N^H, and other strategies will be discussed. Intramolecular S_N^H reactions will also be considered as effective synthetic tools to obtain condensed heterocyclic systems.