Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

Foti, Mario C.; Sharma, Sunil K.; Shakya, Gaurav; Prasad, Ashok K.; Nicolosi, Giovanni; Bovicelli, Paolo; Ghosh, Balaram; Raj, Hanumantharao G.; Rastogi, Ramesh C.; Parmar, Virinder S.

doi:10.1351/pac200577010091

Pure Appl. Chem., 2005, Vol. 77, No. 1, pp. 91-101

http://dx.doi.org/10.1351/pac200577010091

Biopolyphenolics as antioxidants: Studies under an Indo-Italian CSIR-CNR project

Mario C. Foti¹, Sunil K. Sharma², Gaurav Shakya², Ashok K. Prasad², Giovanni Nicolosi¹, Paolo Bovicelli³, Balaram Ghosh⁴, Hanumantharao G. Raj⁵, Ramesh C. Rastogi² and Virinder S. Parmar²

¹ Istituto di Chimica Biomolecolare del CNR, Sezione di Catania, Via del Santuario 110, 95028 Valverde (CT), Italy
² Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India
³ Istituto di Chimica Biomolecolare, CNR, Sezione di Roma, University of La Sapienza, I-00185, Roma, Italy
⁴ Molecular Immunology and Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India
⁵ Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India

Abstract: A wide variety of polyphenolic compounds (i.e., 4-methylcoumarins, xanthones, pyrazoles, and pyrazolylacrylonitriles) have been examined for their antioxidant effect on NADPH-catalyzed liver-microsomal lipid peroxidation with a view to establishing their structure–activity relationship. Dihydroxy-/diacetoxy-4-methylcoumarin derivatives have been shown to be radical scavengers. The effect of nine different xanthones has been examined on the modulation of cytokine-induced expression of intercellular adhesion molecule-1 (ICAM-1) in human endothelial cells. 1,4-Dihydroxyxanthone showed enhanced antioxidant activity as well as ICAM-1 inhibitory activity.