Pure Appl. Chem., 2005, Vol. 77, No. 1, pp. 139-143
doi:10.1351/pac200577010139
Use of furans in synthesis of bioactive compounds*
Hing-Ken Lee, Kin-Fai Chan, Chi-Wai Hui, Ho-Kee Yim, Xun-Wei Wu, and Henry N. C. Wong‡
Department of Chemistry, Institute of Chinese Medicine and Central Laboratory of Institute of Molecular Technology for Drug Discovery and Synthesis, Chinese University of Hong Kong Shatin, New Territories, Hong Kong SAR, China
Abstract:
Synthetic approaches to the total synthesis of plakortone B, as well as diastereoselective nucleophilic additions to furyl aldehyde and furyl sulfonylimine employing chiral 3-boronates as auxiliary are presented.
Keywords: chiral auxiliary; diastereoselectivity; furan; furan-3-boronates; furanmethanols; hydroxypyranones; plakortones.
*Paper based on a presentation at the 24th International Symposium on the Chemistry of Natural Products and the 4th International Congress on Biodiversity, held jointly in Delhi, India, 26-31 January 2004. Other presentations are published in this issue, pp. 1-344.