Pure Appl. Chem., 2005, Vol. 77, No. 1, pp. 195-200
doi:10.1351/pac200577010195
Novel anti-infective compounds*
Vidya B. Lohray‡, Braj. B. Lohray, and Brijesh Kumar Srivastava
Zydus Research Centre, Cadila Healthcare Ltd., Sarkhej-Bavla N. H. No. 8A, Moraiya, Ahmedabad 382 210, India
Abstract:
A set of substituted piperazinyloxazolidinone derivatives has been studied for their antibacterial activity in a few gram-positive bacteria. The structural modifications have provided a superior compound than linezolid, the only drug of this class in the market at present.
Keywords: 3-(4-piperazinophenyl); cinnamoyl group; eperezolid; in vitro MIC; linezolid; molecular modeling; novel antibacterials; oxazolidinones.