Pure Appl. Chem., 2005, Vol. 77, No. 12, pp. 2047-2052
doi:10.1351/pac200577122047
Recent progress in Lewis acid-Lewis base bifunctional asymmetric catalysis*
Motomu Kanai1,2, Nobuki Kato2, Eiko Ichikawa2, and Masakatsu Shibasaki1
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; 2PRESTO, Japan Science and Technology Corporation (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Abstract:
Two enantioselective cyanation reactions, the Strecker reaction of ketoimines and the Reissert reaction of pyridine derivatives, promoted by Lewis acid-Lewis base bifunctional asymmetric catalysts are described.
Keywords: asymmetric catalysis; Bifunctional asymmetric catalysis; cyanation; ketoimines; Reissert reaction; Strecker reaction.
*Paper based on a presentation at the 7th IUPAC International Conference on Heteroatom Chemistry (ICHAC-7), Shanghai, China, 21-25 August 2004. Other presentations are published in this issue, pp. 1985-2132.