Pure Appl. Chem., 2005, Vol. 77, No. 12, pp. 2121-2132
doi:10.1351/pac200577122121
New chiral phosphorus ligands with spirobiindane backbone for asymmetric hydrogenations*
Jian-Hua Xie, Shou-Fei Zhu, Yu Fu, Ai-Guo Hu, and Qi-Lin Zhou
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
Abstract:
Chiral spiro phosphorus ligands including monophosphoramidites and diphosphines, which contained 1,1'-spirobiindane as a backbone, were designed and synthesized. These spiro ligands were proven to be highly efficient for rhodium- and ruthenium-catalyzed asymmetric hydrogenations of prochiral olefins and ketones with excellent enantioselectivities.
Keywords: 1,1'-spirobiindane; asymmetric hydrogenation; chiral spiro phosphorus ligands; Monophosphoramidites; prochiral olefins.
*Paper based on a presentation at the 7th IUPAC International Conference on Heteroatom Chemistry (ICHAC-7), Shanghai, China, 21-25 August 2004. Other presentations are published in this issue, pp. 1985-2132.