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Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1139-1152

doi:10.1351/pac200577071139

Syntheses of antiangiogenic or cytotoxic natural products: Fumagillin and bengacarboline*

O. Bedel, A. Haudrechy, A. Pouilhès, and Y. Langlois

Laboratoire de Synthèse des Substances Naturelles, Associé au CNRS, Université de Paris-Sud, 91405 Orsay, France


Abstract: Syntheses of fumagillol, a precursor of antiangiogenic sesquiterpene fumagillin, and of cytotoxic marine alkaloid bengacarboline are described.

Keywords: antiangiogenic; bengacarboline; fumagillin; fumagillol; sesquiterpene.

*An issue of reviews and research papers based on lectures presented at the 15th International Conference on Organic Synthesis (ICOS-15), held in Nagoya, Japan, 1-6 August 2004, on the theme of organic synthesis. Other presentations are published in this issue, pp. 1087-1296.