Pure Appl. Chem., 2005, Vol. 77, No. 7, pp. 1183-1189
doi:10.1351/pac200577071183
Application of the carbene cyclization-cycloaddition cascade in total synthesis*
Pauline Chiu
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China
Abstract:
The title reaction is a key transformation that has been applied to the synthetic studies of the antitumor and antifungal compounds, the pseudolaric acids.
Keywords: carbenes; carbonyl ylides; dipolar cycloaddition; pseudolaric acid; total synthesis.
*An issue of reviews and research papers based on lectures presented at the 15th International Conference on Organic Synthesis (ICOS-15), held in Nagoya, Japan, 1-6 August 2004, on the theme of organic synthesis. Other presentations are published in this issue, pp. 1087-1296.
All articles from the 15th International Conference on Organic Synthesis (ICOS-15), Nagoya, Japan, 1–6 August 2004.