Pure Appl. Chem., 2006, Vol. 78, No. 12, pp. 2297-2304
doi:10.1351/pac200678122297
Oxidative damage to DNA: Inhibition of guanine damage*
Sriram Kanvah and Gary B. Schuster
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
Abstract:
One-electron oxidation of DNA results in chemical damage to nucleobases, particularly guanine in multiple G sequences. Oxidation may be triggered by numerous events, including photosensitization. We describe studies of photoinduced oxidations of DNA triggered by irradiation of covalently linked anthraquinone derivatives under various conditions that affect the global structure of the DNA. These structural changes have subtle effects on the result of the one-electron oxidation.
Keywords: damage repair; DNA; guanine damage; molecular wire; nanoelectronics; oxidative damage.
*Paper based on a presentation at the XXIst Symposium on Photochemistry, 2-7 April 2006, Kyoto, Japan. Other presentations are published in this issue, pp. 2193-2359.
All articles from the XXIst Symposium on Photochemistry, Kyoto, Japan, 2–7 April 2006.