Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 231-239
doi:10.1351/pac200678020231
Palladium-mediated cascade or multicomponent reactions: A new route to carbo- and heterocyclic compounds*
Geneviève Balme, Didier Bouyssi, and Nuno Monteiro
Laboratoire de Chimie Organique 1, CNRS UMR 5622, Université Claude Bernard, Lyon I, CPE. 43, Blvd. du 11 Novembre 1918, 69622 Villeurbanne, France
Abstract:
In recent years, new processes based on transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilized carbon nucleophiles to unactivated alkenes and alkynes have been developed in our laboratory. In this article, we summarize a number of recent synthetic applications of these new processes. Emphasis is placed on the development of multicomponent reactions based on a Pd-mediated intramolecular cyclization coupled with a carbon-carbon bond-forming reaction. Applications of this methodology to the synthesis of natural lignans are also reported.
Keywords: cascade reactions; heterocycle; multicomponent; palladium; synthesis.
*Pure Appl. Chem. 78, 197-523. An issue of reviews and research papers based on lectures presented at the 13th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-13), Geneva, Switzerland, 17-21 July 2005.