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Pure Appl. Chem., 2006, Vol. 78, No. 9, pp. 1771-1779

Layered double hydroxide nanomaterials as potential cellular drug delivery agents

Zhi Ping Xu and G. Q. (Max) Lu

ARC Centre for Functional Nanomaterials, School of Engineering and Australia Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia

Abstract: This paper briefly reviews the recent progress in using layered double hydroxide (LDH) nanomaterials as cellular delivery agents. The advantages of LDHs as cellular delivery agents are summarized, and the processes of interaction/de-intercalation of anionic drugs (genes) into/from LDH nanoparticles are discussed. Then the cellular delivery of LDH-drug (gene) nanohybrids and subsequent intracellular processes are presumably proposed. At the end, some challenges and remarks for efficient delivery of drugs (genes) via LDH nanoparticles are provided to the best of our knowledge.