Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 615-626
doi:10.1351/pac200779040615
Structural development studies of nuclear receptor ligands*
Shinnosuke Hosoda and Yuichi Hashimoto
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Abstract:
Studies in our laboratory are focused on structural development studies of biological response modifiers (BRMs), including nuclear receptor (NR) ligands, which act directly on cells at the gene expression level, and thalidomide (and related molecules), which modulates a variety of physiological processes. Our studies on the molecular design of ligands for retinoic acid receptor (RAR), androgen receptor (AR), vitamin D receptor (VDR), farnesoid X receptor (FXR), and peroxisome proliferator-activated receptor (PPAR) are reviewed.
Keywords: androgens; antagonists; ligands; nuclear receptors; retinoid; structural development; vitamin D.
*Pure Appl. Chem. 79, 467-823 (2007) pp. 467-823. An issue of reviews and research papers based on lectures presented at the 25th International Symposium on Chemistry of Natural Products (ISCNP-25) and 5th International Conference on Biodiversity (ICOB-5), held jointly in Kyoto, Japan, 23-28 July 2006, on the theme of natural products.
Full text is not freely available, please see subscription information for options to obtain it.
| References (54)