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Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 717-728

http://dx.doi.org/10.1351/pac200779040717

Influence of C-terminal amidation on the antimicrobial and hemolytic activities of cationic α-helical peptides

Erik Strandberg1, Deniz Tiltak2, Marco Ieronimo2, Nathalie Kanithasen2, Parvesh Wadhwani1 and Anne S. Ulrich1,2

1 Institute for Biological Interfaces, Forschungszentrum Karlsruhe, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
2 Institute of Organic Chemistry, University of Karlsruhe, Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany

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  • Dawson Raymond M., Liu Chun-Qiang: Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. Intl J Antimicrob Agents 2011, 37, 432. <http://dx.doi.org/10.1016/j.ijantimicag.2011.01.007>
  • Dawson Raymond M., McAllister Jane, Liu Chun-Qiang: Characterisation and evaluation of synthetic antimicrobial peptides against Bacillus globigii, Bacillus anthracis and Burkholderia thailandensis. Intl J Antimicrob Agents 2010, 36, 359. <http://dx.doi.org/10.1016/j.ijantimicag.2010.06.038>
  • Carter Victoria, Hurd Hilary: Choosing anti-Plasmodium molecules for genetically modifying mosquitoes: focus on peptides. Trends Parasitol 2010, 26, 582. <http://dx.doi.org/10.1016/j.pt.2010.07.005>
  • Dennison Sarah Rachel, Harris Frederick, Bhatt Tailap, Singh Jaipaul, Phoenix David Andrew: The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides. MOL CELL BIOCHEM 2009, 332, 43. <http://dx.doi.org/10.1007/s11010-009-0172-8>
  • Strandberg Erik, Tremouilhac Pierre, Wadhwani Parvesh, Ulrich Anne S.: Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR. Biochim Biophys Acta Biomembr 2009, 1788, 1667. <http://dx.doi.org/10.1016/j.bbamem.2008.12.018>
  • Lohner Karl, Prossnigg Florian: Biological activity and structural aspects of PGLa interaction with membrane mimetic systems. Biochim Biophys Acta Biomembr 2009, 1788, 1656. <http://dx.doi.org/10.1016/j.bbamem.2009.05.012>