Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 753-761
doi:10.1351/pac200779040753
From natural products to biological tools*
Peter Wipf, Thomas H. Graham, and Jingbo Xiao
Department of Chemistry and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA
Abstract:
The development of a total synthetic approach for the antimitotic disorazole C1 and the design of a peptide isostere linked to the reactive oxygen scavenger 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) demonstrate established as well as novel strategies for mining the therapeutic potential of natural products.
Keywords: antimitotic; disorazole; gramicidin S; mitochondria; natural products.
*Pure Appl. Chem. 79, 467-823 (2007) pp. 467-823. An issue of reviews and research papers based on lectures presented at the 25th International Symposium on Chemistry of Natural Products (ISCNP-25) and 5th International Conference on Biodiversity (ICOB-5), held jointly in Kyoto, Japan, 23-28 July 2006, on the theme of natural products.
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