Pure Appl. Chem., 2007, Vol. 79, No. 4, pp. 753-761
From natural products to biological tools
Abstract: The development of a total synthetic approach for the antimitotic disorazole C1 and the design of a peptide isostere linked to the reactive oxygen scavenger 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) demonstrate established as well as novel strategies for mining the therapeutic potential of natural products.