Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1047-1053
doi:10.1351/pac200880051047
Hydrogenation of polar functionalities with Cp*Ru(PN) catalysts*
Masato Ito
Department of Applied Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo 152-8552, Japan
Abstract:
This account deals with an overview of our recent progress toward the development of molecular catalysts for the reduction in polar functionalities with molecular hydrogen (H2). An emphasis is placed on the newly designed Cp*Ru(PN) complexes, which have been identified as efficient catalysts for the hydrogenation of imides. The structural modification of the complex enhances the catalytic performance and allows efficient access to various chiral synthetic intermediates.
Keywords: Cp*Ru(PN) complexes; hydrogenation; imides; paroxetine; polar functionality.
*Paper based on a presentation at the 14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-14), 2-6 August 2007, Nara, Japan. Other presentations are published in this issue, pp. 807-1194.