Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1161-1166
doi:10.1351/pac200880051161
Palladium-catalyzed cross-addition of triisopropylsilylacetylene to unactivated alkynes*
Naofumi Tsukada, Satoshi Ninomiya, Yoshimi Aoyama, and Yoshio Inoue
Graduate School of Engineering, Tohoku University, Aoba, Sendai 980-8579, Japan
Abstract:
Selective cross-addition of triisopropylsilylacetylene (TIPSA) to unactivated alkynes is catalyzed by dinuclear and mononuclear palladium complexes supported by a multidentate ligand, N,N'-bis[2-(diphenylphosphino)phenyl]formamidine (dpfamH). While the addition reactions of TIPSA to dialkylacetylenes using palladium catalysts supported by monodentate and bidentate ligands gives dimers of TIPSA as major products, the reactions with the palladium complexes supported by dpfam affords cross-adducts selectively, in which the yields of TIPSA dimers are less than 5 %. The addition of TIPSA to monoalkylacetylenes also gives cross-adducts as major products, although the selectivity and yield are moderate.
Keywords: alkyne; cross-addition; dimerization; dinuclear complex; palladium.
*Paper based on a presentation at the 14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-14), 2-6 August 2007, Nara, Japan. Other presentations are published in this issue, pp. 807-1194.
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