Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 1167-1177
doi:10.1351/pac200880051167
New cyclizations via catalytic ruthenium vinylidenes*
Jesús A. Varela, Carlos González-Rodríguez, Silvia G. Rubín, Luis Castedo, and Carlos Saá
Department of Organic Chemistry, Faculty of Chemistry, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Abstract:
New carbocyclizations that proceed via catalytic metal-vinylidenes are presented. Metal-vinylidene catalytic species, which are easily accessible from terminal alkynes and catalytic amounts of transition-metal complexes, can be involved either in pericyclic reactions or in tandem processes triggered by nucleophilic attack at the electrophilic position of the vinylidene. In both cases, a wide variety of valuable cyclic compounds are easily accessible. Some recent carbocyclizations will be described.
Keywords: carbocycles; cyclizations; metal-vinylidenes; nucleophilic additions; pericyclic reactions.
*Paper based on a presentation at the 14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS-14), 2-6 August 2007, Nara, Japan. Other presentations are published in this issue, pp. 807-1194.
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