Pure Appl. Chem., 2008, Vol. 80, No. 8, pp. 1683-1691
doi:10.1351/pac200880081683
Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities*
Sebastien Reymond, Laurent Ferrié, Amandine Guérinot, Patrice Capdevielle, and Janine Cossy
Laboratoire de Chimie Organique ESPCI-Paris Tech, CNRS, 10 Rue Vauquelin, 75231 Paris Cedex 05, France
Abstract:
Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A.
Keywords: allyltitanation; chemoselective reactions; cross-coupling; cross-metathesis; crotyltitanation; iron; natural products; ring-closing metathesis; total synthesis.
Full text is not freely available, please see subscription information for options to obtain it.
| References (51)
All articles from the 41st IUPAC World Chemistry Congress, Turin, Italy, 5–11 August 2007.