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Pure Appl. Chem., 2009, Vol. 81, No. 6, pp. 1051-1063

http://dx.doi.org/10.1351/PAC-CON-08-10-16

Published online 2009-05-05

Discovery of anticancer agents of diverse natural origin

A. Douglas Kinghorn1*, Esperanza J. Carcache de Blanco1, Hee-Byung Chai1, Jimmy Orjala2, Norman R. Farnsworth2, D. Doel Soejarto2, Nicholas H. Oberlies3, Mansukh C. Wani3, David J. Kroll3*, Cedric J. Pearce4, Steven M. Swanson2, Robert A. Kramer5, William C. Rose5, Craig R. Fairchild5, Gregory D. Vite5, Stuart Emanuel5, David Jarjoura6 and Frederick O. Cope6

1 College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
2 College of Pharmacy, The University of Illinois at Chicago, Chicago, IL 60612, USA
3 Research Triangle Institute, Research Triangle Park, NC 27709, USA
4 Mycosynthetix, Inc., Hillsborough, NC 27278, USA
5 Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543, USA
6 Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

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  • Pan Li, Yong Yeonjoong, Deng Ye, Lantvit Daniel D., Ninh Tran Ngoc, Chai Heebyung, Carcache de Blanco Esperanza J., Soejarto Djaja D., Swanson Steven M., Kinghorn A. Douglas: Isolation, Structure Elucidation, and Biological Evaluation of 16,23-Epoxycucurbitacin Constituents from Eleaocarpus chinensis. Journal of Natural Product 2012, 120112143136004. <http://dx.doi.org/10.1021/np200879p>
  • D’Ambrosio Steven M., Han Chunhua, Pan Li, Douglas Kinghorn A., Ding Haiming: Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway. BIOPHYS BIOCHEM RES COMMUN 2011, 409, 465. <http://dx.doi.org/10.1016/j.bbrc.2011.05.027>
  • Chin Young-Won, Chai Hee-Byung, Deng Ye, de Blanco Esperanza Carcache, Kardono Leonardus B.S., Riswan Soedarsano, Soejarto Djaja D., Farnsworth Norman R., Kinghorn A. Douglas: Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinata. Phytochem Lett 2011, 4, 213. <http://dx.doi.org/10.1016/j.phytol.2011.03.007>
  • Ayers Sloan, Ehrmann Brandie M., Adcock Audrey F., Kroll David J., Wani Mansukh C., Pearce Cedric J., Oberlies Nicholas H.: Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. Tetrahetron Lett 2011, 52, 5733. <http://dx.doi.org/10.1016/j.tetlet.2011.08.125>
  • Ren Yulin, Matthew Susan, Lantvit Daniel D., Ninh Tran Ngoc, Chai Heebyung, Fuchs James R., Soejarto Djaja D., de Blanco Esperanza J. Carcache, Swanson Steven M., Kinghorn A. Douglas: Cytotoxic and NF-κB Inhibitory Constituents of the Stems of Cratoxylum cochinchinense and Their Semisynthetic Analogues. J Nat Prod 2011, 74, 1117. <http://dx.doi.org/10.1021/np200051j>
  • Ayers Sloan, Graf Tyler N., Adcock Audrey F., Kroll David J., Matthew Susan, Carcache de Blanco Esperanza J., Shen Qi, Swanson Steven M., Wani Mansukh C., Pearce Cedric J.: Resorcylic Acid Lactones with Cytotoxic and NF-κB Inhibitory Activities and Their Structure–Activity Relationships. J Nat Prod 2011, 74, 1126. <http://dx.doi.org/10.1021/np200062x>
  • Kinghorn A. Douglas, Pan Li, Fletcher Joshua N., Chai Heebyung: The Relevance of Higher Plants in Lead Compound Discovery Programs. J Nat Prod 2011, 74, 1539. <http://dx.doi.org/10.1021/np200391c>
  • Sy-Cordero Arlene A., Graf Tyler N., Adcock Audrey F., Kroll David J., Shen Qi, Swanson Steven M., Wani Mansukh C., Pearce Cedric J., Oberlies Nicholas H.: Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320). Journal of Natural Product 2011, 74, 2137. <http://dx.doi.org/10.1021/np2004243>
  • Pan Li, Lantvit Daniel D., Riswan Soedarsono, Kardono Leonardus B.S., Chai Hee-Byung, Carcache de Blanco Esperanza J., Farnsworth Norman R., Soejarto Djaja Doel, Swanson Steven M., Kinghorn A. Douglas: Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa. Phytochemisry 2010, 71, 635. <http://dx.doi.org/10.1016/j.phytochem.2010.01.012>
  • Sy-Cordero Arlene A, Graf Tyler N, Wani Mansukh C, Kroll David J, Pearce Cedric J, Oberlies Nicholas H: Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles. J Antibiot 2010, 63, 539. <http://dx.doi.org/10.1038/ja.2010.77>