Pure Appl. Chem., 2010, Vol. 82, No. 9, pp. 1835-1844
Published online 2010-05-30
Synthesis of heterocycles via alkoxyallenes
Abstract: Lithiated alkoxyallenes are very versatile components for the synthesis of heterocycles such as furans, pyrroles, and 1,2-oxazines, easily allowing the preparation of natural products via these heterocyclic intermediates. A surprising three-component synthesis of N‑acylated enaminones allowed the synthesis of highly functionalized 4-hydroxypyridines, 5‑acetyloxazoles, and pyrimidines. All these heterocyclic products are ready for further functionalizations, in particular for palladium-catalyzed reactions, leading to libraries of new interesting heterocycles.