Pure Appl. Chem., 2012, Vol. 84, No. 6, pp. 1445-1453
Published online 2012-04-02
Synthesis of saxitoxins
Abstract: Saxitoxin (STX), a neurotoxin isolated from Alaskan butter clam, Saxidomus giganteus, inhibits voltage-gated sodium channels by binding to the pore-forming p-loop region. Here we describe stereospecific syntheses of STX and its natural derivatives, (+)‑decarbamoylsaxitoxin (dcSTX) and (+)-gonyautoxin3 (GTX3).
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