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Pure Appl. Chem., 2012, Vol. 84, No. 9, pp. 1867-1875

http://dx.doi.org/10.1351/PAC-CON-11-10-21

Published online 2012-04-29

First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme

Néstor M. Carballeira1*, Michelle Cartagena1, Fengyu Li1, Zhongfang Chen1, Christopher F. Prada2, Estefania Calvo-Alvarez2, Rosa M. Reguera2 and Rafael Balaña-Fouce2

1 Department of Chemistry, University of Puerto Rico, Rio Piedras campus, P.O. Box 23346, San Juan, Puerto Rico
2 Department of Biomedical Sciences, University of León, Campus de Vegazana s/n, 24071 León, Spain

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