| Number: | 2002-036-1-500 |
|---|---|
| Start: | 01 January 2003 |
Series: Solubility Data Series; editor-in-chief: Mark Salomon
Hydroxybenzoic acids and related compounds are pharmaceutically important substances. In particular, 2-hydroxybenzoic acid has been widely used as a medicine and a preservative for food products; 4-hydroxybenzoic acid alkyl esters have also been used as preservatives for food. The relation between the use of these substances and human health requires evaluation of the solubilities of 2-, 3-, and 4-monohydroxybenzoic acids and of 4-hydroxybenzoic acid alkyl esters in water, organic and mixed solvents. It is also suggested to evaluate the solubilities of: (a) 2- and 3-hydroxybenzoic acid in supercritical carbon dioxide containing organic solvents such as methanol and acetone; (b) monohydroxybenzoates, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5- dihydroxybenzoic acid salts of alkali, transition and rare earth metals in water and organic solvents.
All of the solubility data of hydroxyl benzoic acids and hydroxybenzoates have been compiled. A total of 177 original studies treating ternary systems published from 1898 to 2001 has been carried out. The solubilities of hydroxyl benzoic acids and alkyl p hydroxybenzoates in water and in various alcohols could be statistically evaluated at various temperatures.
> Nov 2004 report update (pdf file - 11KB)
> May 2006 report update (pdf file - 14KB)
To be published as part of the IUPAC-NIST Solubility Data Series. in J. Phys. Chem. Ref. Data; estimated to be completed during 2006.
> July 2007 report update (pdf file - 13KB)