IUPAC

Series: Solubility Data Series; editor-in-chief: Mark Salomon

 The solubilities of antibiotics are of major importance in pharmaceutical and medicinal chemistry. For example, drug delivery formulations which directly relate to anti-bacterial activities depend strongly on solubility. The search for new antibiotics resistant to continually evolving bacterial strains is a major focus of drug R&D worldwide, and here solubilities are important in helping the design processes. The compilation and, where possible, critical evaluation of solubilities for these compounds can be expected to play a major role in the design and delivery of chemotherapeutic drugs now undergoing extensive R&D.
Compilations are available already for many peptide and macrocyclic lactone antibiotics, with literature surveyed up to about 1985. The compilations need to be extended to cover more modern work and other antibiotics belonging to these two classes. Task group members with this expertise are being recruited.
In this project, solubilities of two classes of antibiotics in both aqueous and non-aqueous solvents are compiled, and critical evaluations are made in the few cases where sufficient reliable data are available. The two classes are peptide antibiotics (such as actinomycin) and macrocyclic lactone antibiotics (such as erythromycin).

To be published as part of the IUPAC-NIST Solubility Data Series. in J. Phys. Chem. Ref. Data.

Project postponed