IUPAC

Biological monitoring of exposure to volatile organic solvents is used for the evaluation of internal exposure. On the basis of dose-effect and dose-response relationships, the health based recommendations of the admissible concentrations of unchanged substances or metabolites can be proposed. Unfortunately in a majority of published papers only relations between the concentrations in air and biological material are presented, without the background information on the conditions of sample collection and sample strategy that have to be based on toxicokinetic data (t1/2, metabolic parameters). The objective of this study is to evaluate the existing data on collection of samples, sampling strategy and the possibility of interpretation of the results. This will result in a proposal of practical recommendations.

The working party presented an improved version at the Geneva GA. It will be revised and discussed for the last time during a special meeting in Copenhagen at the end of November 97.

A provisional document has been prepared and distributed for review. The public comment period will end 29 fev. 2000.

Project completed - IUPAC Recommendations published in Pure Appl. Chem., 72(3), 385-436, 2000.