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Pure Appl. Chem. 75(2-3), 389-393, 2003

Pure and Applied Chemistry

Vol. 75, Issue 2-3

Biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum

L. Ning, H. Guo, X. Jiang, K. Bi, and D. Guo

1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P. R. China; 2Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P. R. China

Abstract: The biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum was investigated. After six days of incubation, five products were obtained. On the basis of chemical and spectral evidence, their structures were elucidated as epitriptolide-14-O-b-D-glucoside, 5a-hydroxytriptonide, triptolide, triptodiolide, and 2b-hydroxytriptonide, among which epitriptolide-14-O-b-D-glucoside and 5a-hydroxytriptonide are new compounds.

*Pure Appl.Chem. 75, 141�419 (2003). An issue of reviews and research papers based on lectures presented at the 23rd IUPAC International Symposium on the Chemistry of Natural Products, Florence, Italy, 28 July � 2 August 2002.


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