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Pure Appl. Chem. 75(11/12), 1949-1953, 2003

Pure and Applied Chemistry

Vol. 75, Issues 11-12

Environmental fate and metabolism: Issues and recommendations

P. de Voogt, B. Halling-S�rensen, B. van Hattum, P. T. Holland, F. Ingerslev, A. Johnson, M. J�rgens, A. Katayama, W. Klein,* N. Kurihara, J. C. Leblanc, K. D. Racke, T. Sanderson, M. Shemesh, L. S. Shore, et. al.

* Fraunhofer Institute for Molecular Biology and Applied Ecology, 57392 Schmallenberg, Germany

Abstract: This main topic of the project and symposium includes the issue of releases of EASs and their monitoring in the environment, food, and feed in order to provide the full set of criteria, relevant for exposure assessment. Much less research has been devoted to these areas as compared to investigations on the effects. Issues of special importance regarding exposure to EASs, both from a research and risk management point of view, predominantly result from the fact that high-potency natural products are released as well as anthropogenic substances.

In order to provide reliable information for risk assessment and risk management, substantial research, methodological improvements, and improvements in data interpretation are needed regarding the following: releases and technologies for their mitigation; monitoring; establishment of background levels; transport, partitioning, persistence, degradation, and metabolism of EASs; dealing with "joint toxicity"; and providing reliable analytical methodology conforming to the principles of quality assurance.

Phytohormones play a special role in this whole area since they may be used as food amendments.

*Report from a SCOPE/IUPAC project: Implication of Endocrine Active Substances for Human and Wildlife (J. Miyamoto and J.Burger, editors). Other reports are published in this issue, pp. 1617-2615.


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