Pure Appl. Chem., 2001, Vol. 73, No. 6, pp. 993-1031
CHEMISTRY AND HUMAN HEALTH DIVISION
CLINICAL CHEMISTRY SECTION
COMMISSION ON TOXICOLOGY
Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report)
Abstract: This paper reviews the methodology available for risk assessment of exposure to substances in the workplace. Assessment starts with the identification and classification of hazard, which must be related to the doseeffect and doseresponse information available for the hazards identified. Once the potential for exposure has been characterized, it should be quantified and compared with an established safe exposure level. The degree to which it exceeds that level is a measure of the risk. Even if the assessed risk is regarded as acceptable, there is the possibility that the situation will change with time, so it is important to monitor potentially harmful exposures. Factors relevant to effective monitoring are reviewed. Addresses of Internet sites where further information may be obtained are listed along with further reading.