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Pure Appl. Chem., 2001, Vol. 73, No. 7, pp. 1173-1188

http://dx.doi.org/10.1351/pac200173071173

From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin

Anne Robert, Françoise Benoit-Vical, Odile Dechy-Cabaret and Bernard Meunier

Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, 31077 Toulouse Cedex 4, France

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  • Abolaji Amos O., Eteng Mbeh U., Ebong Patrick E., Brisibe Ebiamadon Andi, Dar Ahsana, Kabir Nurul, Choudhary M. Iqbal: A Safety Assessment of the Antimalarial Herb Artemisia annua During Pregnancy in Wistar Rats. Phytother. Res. 2013, 27, 647. <http://dx.doi.org/10.1002/ptr.4760>
  • Persico Marco, Parapini Silvia, Chianese Giuseppina, Fattorusso Caterina, Lombardo Marco, Petrizza Luca, Quintavalla Arianna, Rondinelli Francesca, Basilico Nicoletta, Taramelli Donatella, Trombini Claudio, Fattorusso Ernesto, Taglialatela-Scafati Orazio: Further optimization of plakortin pharmacophore: Structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity. European Journal of Medicinal Chemistry 2013, 70, 875. <http://dx.doi.org/10.1016/j.ejmech.2013.10.050>
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  • Rajan A., Bagai U., Chandel S.: Effect of artesunate based combination therapy with homeopathic medicine china on liver and kidney of Plasmodium berghei infected mice. J Parasit Dis 2012. <http://dx.doi.org/10.1007/s12639-012-0132-1>
  • Fromentin Yann, Grellier Philippe, Wansi Jean Duplex, Lallemand Marie-Christine, Buisson Didier: Yeast-Mediated Xanthone Synthesis through Oxidative Intramolecular Cyclization. Org. Lett. 2012, 14, 5054. <http://dx.doi.org/10.1021/ol302283p>
  • Muthaura C.N., Keriko J.M., Derese S., Yenesew A., Rukunga G.M.: Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs. Experimental Parasitology 2011, 127, 609. <http://dx.doi.org/10.1016/j.exppara.2010.11.004>
  • Persico Marco, Quintavalla Arianna, Rondinelli Francesca, Trombini Claudio, Lombardo Marco, Fattorusso Caterina, Azzarito Valeria, Taramelli Donatella, Parapini Silvia, Corbett Yolanda: A New Class of Antimalarial Dioxanes Obtained through a Simple Two-Step Synthetic Approach: Rational Design and Structure–Activity Relationship Studies. J Med Chem 2011, 54, 8526. <http://dx.doi.org/10.1021/jm201056j>
  • Kwansa-Bentum Bethel, Ayi Irene, Suzuki Takashi, Otchere Joseph, Kumagai Takashi, Anyan William K., Asahi Hiroko, Akao Nobuaki, Wilson Michael D., Boakye Daniel A.: Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment : Treating uncomplicated malaria in southern Ghana. Tropical Med Int Health 2011, 16, 1215. <http://dx.doi.org/10.1111/j.1365-3156.2011.02833.x>
  • Taglialatela-Scafati Orazio, Fattorusso Ernesto, Romano Adriana, Scala Fernando, Barone Vincenzo, Cimino Paola, Stendardo Emiliano, Catalanotti Bruno, Persico Marco, Fattorusso Caterina: Insight into the mechanism of action of plakortins, simple 1,2-dioxane antimalarials. Org Biomol Chem 2010, 8, 846. <http://dx.doi.org/10.1039/b918600j>
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  • Hyun Park Sang, Jeong Gwon Hui, Pradeep Kannampalli: Synthesis and biological evaluation of131I-labelled pyronaridine. J Labelled Cpd Radiopharm 2007, 50, 123. <http://dx.doi.org/10.1002/jlcr.1202>
  • Cînt??-Pînzaru S., Peica N., Küstner B., Schlücker S., Schmitt M., Frosch T., Faber J. H., Bringmann G., Popp J.: FT-Raman and NIR-SERS characterization of the antimalarial drugs chloroquine and mefloquine and their interaction with hematin. J Raman Spectrosc 2006, 37, 326. <http://dx.doi.org/10.1002/jrs.1471>
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  • Marconi Giancarlo, Monti Sandra, Manoli Francesco, Degli Esposti Alessandra, Mayer Bernd: A circular dichroism and structural study of the inclusion complex artemisinin-β-cyclodextrin. chem phys letts 2004, 383, 566. <http://dx.doi.org/10.1016/j.cplett.2003.11.084>
  • Alberti Angelo, Macciantelli Dante, Marconi Giancarlo: Free radicals formed by addition of antimalaric artemisinin (Qinghaosu, QHS) to human serum: an ESR-spin trapping investigation. Res. Chem. Intermed. 2004, 30, 615. <http://dx.doi.org/10.1163/1568567041570366>