Pure Appl. Chem., 2008, Vol. 80, No. 8, pp. 1683-1691
http://dx.doi.org/10.1351/pac200880081683
Chemoselective reactions: Toward the synthesis of biologically active natural products with anticancer activities
Abstract:
Leucascandrolide A and migrastatin were synthesized efficiently by using chemoselective reactions such as olefin metatheses. The use of an iron-catalyzed cross-coupling reaction overcame difficulties encountered with palladium-catalyzed processes in our synthetic approach toward spirangien A.
Keywords
allyltitanation; chemoselective reactions; cross-coupling; cross-metathesis; crotyltitanation; iron; natural products; ring-closing metathesis; total synthesis.