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Pure Appl. Chem., 2009, Vol. 81, No. 6, pp. 1041-1049

http://dx.doi.org/10.1351/PAC-CON-08-11-08

Published online 2009-05-05

Isolation and characterization of jadomycin L from Streptomyces venezuelae ISP5230 for solid tumor efficacy studies

David L. Jakeman1*, Stephanie N. Dupuis2 and Cathy L. Graham1

1 College of Pharmacy, Dalhousie University, 5968 College St., Halifax, NS, B3H 3J5, Canada
2 Department of Chemistry, Dalhousie University, Halifax, NS, B3H 4J3, Canada

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  • Issa Mark E., Hall Steven R., Dupuis Stephanie N., Graham Cathy L., Jakeman David L., Goralski Kerry B.: Jadomycins are cytotoxic to ABCB1-, ABCC1-, and ABCG2-overexpressing MCF7 breast cancer cells. Anti-Cancer Drugs 2014, 25, 255. <http://dx.doi.org/10.1097/CAD.0000000000000043>
  • Fan Keqiang, Zhang Xia, Liu Hongchun, Han Hui, Luo Yuanming, Wang Qian, Geng Meiyu, Yang Keqian: Evaluation of the cytotoxic activity of new jadomycin derivatives reveals the potential to improve its selectivity against tumor cells. J Antibiot 2012, 65, 449. <http://dx.doi.org/10.1038/ja.2012.48>
  • Dupuis Stephanie N., Robertson Andrew W., Veinot Thomas, Monro Susan M. A., Douglas Susan E., Syvitski Ray T., Goralski Kerry B., McFarland Sherri A., Jakeman David L.: Synthetic diversification of natural products: semi-synthesis and evaluation of triazole jadomycins. Chem Sci 2012, 3, 1640. <http://dx.doi.org/10.1039/c2sc00663d>
  • Dupuis Stephanie N., Veinot Thomas, Monro Susan M. A., Douglas Susan E., Syvitski Raymond T., Goralski Kerry B., McFarland Sherri A., Jakeman David L.: Jadomycins Derived from the Assimilation and Incorporation of Norvaline and Norleucine. Journal of Natural Product 2011, 74, 2420. <http://dx.doi.org/10.1021/np200689w>
  • Shan Mingde, Sharif Ehesan U., O'Doherty George A.: Total Synthesis of Jadomycin A and a Carbasugar Analogue of Jadomycin B. Angew. Chem. 2010, 122, 9682. <http://dx.doi.org/10.1002/ange.201005329>
  • Shan Mingde, Sharif Ehesan U., O'Doherty George A.: Total Synthesis of Jadomycin A and a Carbasugar Analogue of Jadomycin B. Angew. Chem. Int. Ed. 2010, 49, 9492. <http://dx.doi.org/10.1002/anie.201005329>